A HUMANIZED MOUSE MODEL OF DE NOVO HUMAN ACUTE MYELOID LEUKEMIA WITH A MATCHING HUMAN IMMUNE SYSTEM

摘要

Method of producing a non-human mammal that is a model for human NPM1c⁺ acute myeloid leukemia are described, as well as a viral vector useful in producing the non-human mammal. Also described are methods of identifying one or more agents that can be used to treat human acute myeloid leukemia using the non-human mammals.