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COMBINED MEDICATION EFFICACY PROCESSING METHOD AND APPARATUS

机译:联合用药效率处理方法和装置

摘要

Provided are a processing method and apparatus for combined medication efficacy. Said processing method comprises: obtaining the dose-effect curve band of expected additive effect of the combined medications(S202); obtaining the actual dose-effect relationship curve formed by the actual effect value varying with the dose of one target component medicine in the combined medications(S204); comparing the positional relationship between the actual dose-effect relationship curve and the dose-effect curve band(S206); and outputting the efficacy of the combined medications as a synergistic effect when the actual dose-effect relationship curve is located above the dose-effect curve band, outputting the efficacy of the combined medications as antagonistic when the actual dose-effect relationship curve is located below the dose-effect curve band, and outputting the efficacy of the combined medications as addition when the actual dose-effect relationship curve is within the range of the dose-effect curve band (S208). The processing method not only solves the problem that the efficacy cannot be accurately detected when the multiple medicines are combined in the prior art, but also can be widely applied in the research and development, toxicology research, efficacy and safety evaluation of combined medications and environment evaluation for compound medicine.
机译:提供了一种用于联合药物功效的处理方法和装置。所述处理方法包括:获得所述组合药物的预期累加作用的剂量效应曲线带(S202);获得由实际效果值随联合用药中一种靶成分药物的剂量变化而形成的实际剂量-效果关系曲线(S204);比较实际剂量效应关系曲线和剂量效应曲线带之间的位置关系(S206);当实际剂量-效果关系曲线位于剂量-效果曲线带上方时,输出组合药物的功效为协同作用;当实际剂量-效果关系曲线位于下方时,输出组合药物的功效为拮抗作用剂量效果曲线带,当实际的剂量效果关系曲线在剂量效果曲线带的范围内时,输出组合药物的功效作为加法(S208)。该处理方法不仅解决了现有技术中多种药物合用时不能准确检测功效的问题,而且可以广泛应用于组合药物和环境的研发,毒理学研究,功效和安全性评价中。复方药物评估。

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