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COMBINED MEDICATION EFFICACY PROCESSING METHOD AND APPARATUS

机译:联合用药效率处理方法和装置

摘要

Provided are a processing method and a processing apparatus for efficacy of a combined drug. The processing method includes: obtaining a dose-effect curve band of an expected additive effect of the combined drug (S202); obtaining an actual dose-effect relationship curve formed by an actual effect value of the combined drug with a dose change of one target component drug in the combined drug (S204); comparing a positional relationship between the actual dose-effect relationship curve and the dose-effect curve band (S206); and outputting the efficacy of the combined drug as a synergistic effect when the actual dose-effect relationship curve is located above the dose-effect curve band, outputting the efficacy of the combined drug as an antagonistic effect when the actual dose-effect relationship curve is located below the dose-effect curve band, and outputting the efficacy of the combined drug as an additive effect when the actual dose-effect relationship curve is located within a range of the dose-effect curve band (S208). The processing method not only solves the problem that the efficacy cannot be accurately detected when multiple drugs are combined in the conventional art, but also can be widely applied in research and development as well as toxicology research of a compound drug, efficacy and safety evaluation of the combined drug and environment evaluation.
机译:提供了一种用于组合药物功效的处理方法和处理设备。所述处理方法包括:获得所述组合药物的预期累加作用的剂量效应曲线带(S202);获得由所述联合药物的实际作用值与所述联合药物中一种靶成分药物的剂量变化形成的实际剂量效应关系曲线(S204);比较实际剂量效应关系曲线和剂量效应曲线带之间的位置关系(S206);当实际剂量效应关系曲线位于剂量效应曲线带的上方时,输出组合药物的功效为协同作用;当实际剂量效应关系曲线为0时,输出组合药物的功效为拮抗作用。位于剂量效应曲线带下方的位置,并且当实际剂量效应关系曲线位于剂量效应曲线带的范围内时,输出组合药物的功效作为加性效应(S208)。该处理方法不仅解决了现有技术中多种药物合用时不能准确检测功效的问题,而且可以广泛应用于复合药物的研发和毒理研究,功效和安全性评价。药物和环境综合评估。

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