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BIOASSAY FOR MITOCHONDRIAL RESISTANCE TO CELLULAR STRESS

机译：线粒体抗细胞应激的生物测定

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摘要

A method for selecting for cells that are resistant to stress by culturing in vitro a plurality of cells, exposing the cells to a stressor, and measuring the amount of stressor required to inhibit mitochondrial membrane potential of cells can also be used for selecting an oocyte that is competent for in vitro fertilization. Likewise, the method can be used for selecting an embryo isolated in vitro that is competent for subsequent implantation, and for optimizing the likelihood of a live birth after implantation of a human egg fertilized in vitro. Also described is a method of optimizing anti-oxidant treatment for a patient, such as a patient suffering from cancer or diabetes, or from a disorder associated with apoptosis, cellular stress, and/or oxidation.

机译：通过体外培养多个细胞，将细胞暴露于应激源，并测量抑制细胞线粒体膜电位所需的应激源的量来选择抗应激细胞的方法也可以。用于选择能够进行体外受精的卵母细胞。同样，该方法可用于选择能分离出的体外胚胎，该胚胎可用于随后的植入，并用于优化在体外受精的人卵植入后的活产的可能性。 / I>。还描述了一种针对患者例如患有癌症或糖尿病或患有与细胞凋亡，细胞应激和/或氧化有关的病症的患者优化抗氧化剂治疗的方法。 展开▼

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公开/公告号WO2017058900A1

专利类型

公开/公告日2017-04-06

原文格式PDF

申请/专利权人 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;
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申请/专利号WO2016US54160

发明设计人 CHAZENBALK GREGORIO;DUMESIC DANIEL;
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申请日2016-09-28

分类号G01N33/50;

国家 WO

入库时间 2022-08-21 13:31:31

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专利

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中文文献

1. 保护细胞免受氧化和线粒体应激影响的组合物 [P] . 中国专利： CN112423726A . 2021-02-26

2. 一种抗细胞色素B5异构体B抗体及其在纯化线粒体中的应用 [P] . 中国专利： CN102827276A . 2012-12-19

3. Analyzing multi-stress resistance of animal/vegetable cell by subjecting healthy/cancerous cell or sample with set of non-stressing/stressing effectors, and measuring growth, cellular viability and/or oxidative stress of cell or sample [P] . 法国专利： FR2971850A1 . 2012-08-24

机译：通过对健康/癌性细胞或样品施加一组非应激/应激效应物，并测量细胞或样品的生长，细胞活力和/或氧化应激，来分析动物/植物细胞的多重应激抗性

4. In vitro detection of resistance to oxaliplatin in cancer cells, by measuring mitochondrial apoptosis, and the use of stimulators of mitochondrial apoptosis to overcome resistance [P] . 法国专利： FR2840923A1 . 2003-12-19

机译：通过测量线粒体凋亡来体外检测癌细胞中对奥沙利铂的耐药性，并利用线粒体凋亡刺激剂克服耐药性

5. STRESS-RESISTANCE-IMPARTING COMPOSITION, METHOD FOR IMPARTING STRESS RESISTANCE, STRESS RESISTANCE IN-VIVO BREEDING METHOD, AND STRESS EVALUATION METHOD [P] . 世界知识产权组织专利： WO2016152911A1 . 2016-09-29

机译：赋予抗应力的组合物，赋予抗应力的方法，抗应力活体育种法和应力评价法

1. GmGPDH12,a mitochondrial FAD-GPDH from soybean,increases salt and osmotic stress resistance by modulating redox state and respiration [J] . Ying Zhao, Chunyan Liu, Xiaoxia Wu, 作物学报（英文版） . 2021,第001期

2. GmGPDH12,a mitochondrial FAD-GPDH from soybean, increases salt and osmotic stress resistance by modulating redox state and respiration [J] . Ying Zhao, Xin Li, Zexin Zhang, 作物学报：英文版 . 2021,第001期

3. Association between heat stress and oxidative stress in poultry;mitochondrial dysfunction and dietary interventions with phytochemicals [J] . Abdollah, Akbarian, Joris, 畜牧与生物技术杂志：英文版 . 2017,第001期

4. Association between heat stress and oxidative stress in poultry;mitochondrial dysfunction and dietary interventions with phytochemicals [J] . Abdollah Akbarian, Joris Michiels, Jeroen Degroote, 畜牧与生物技术杂志(英文版) . 2017,第001期

5. Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance [J] . Berry Brandon J., Trewin Adam J., Milliken Alexander S., EMBO reports . 2020,第4期

6. Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance [J] . Berry Brandon J., Trewin Adam J., Milliken Alexander S., EMBO reports . 2020,第4期

7. Mitochondrial localization of fission yeast manganese superoxide dismutase is required for its lysine acetylation and for cellular stress resistance and respiratory growth. [J] . Takahashi H, Suzuki T, Shirai A, Biochemical and Biophysical Research Communications . 2011,第1期

8. Multiple stressing bioassays of environmental-related mixtures: the case of hydrolyzed proteins [C] . ANTONIELLI Livio, CORTE Laura, ROSCINI Luca, Microbial diversity 2011 : environmental stress and adaptation . 2011

9. Targeting 8-oxoguanine DNA glycosylase to mitochondria enhances mitochondrial DNA repair and cellular resistance to oxidative stress. [D] . Dobson, Allison Williams. 2001

10. Optogenetic control of mitochondrial protonmotive force to impact cellular stress resistance [O] . Brandon J Berry, Adam J Trewin, Alexander S Milliken, 2020

11. Poster session 2Morphogenetic mechanisms290MiR-133 regulates retinoic acid pathway during early cardiac chamber specification291Bmp2 regulates atrial differentiation through miR-130 during early heart looping formationDevelopmental genetics294Association of deletion allele of insertion/deletion polymorphism in alpha 2B adrenoceptor gene and hypertension with or without type 2 diabetes mellitus295Association of G1359A polymorphism of the endocannabinoid type 1 receptor (CNR1) with coronary artery disease (CAD) with type 2 diabetes mellitusCell growth, differentiation and stem cells - Vascular298Gamma-secretase inhibitor prevents proliferation and migration of ductus arteriosus smooth muscle cells: a role of Notch signaling in postnatal closure of ductus arteriosus299Mesenchymal stromal-like cells (MLCs) derived from induced pluripotent stem (iPS) cells: a promising therapeutic option to promote neovascularization300Sonic Hedgehog promotes mesenchymal stem cell differentiation to vascular smooth muscle cells in cardiovacsular disease301Proinflammatory cytokine secretion and epigenetic modification in endothelial cells treated LPS-GinfivalisCell death and apoptosis - Vascular304Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipidsTranscriptional control and RNA species - Vascular307MicroRNA-34a role in vascular calcification308Local delivery of a miR-146a inhibitor utilizing a clinically applicable approach attenuates neointima formation after vascular injury309Long noncoding RNA landscape of hypoxic endothelial cells310Specific circulating microRNAs levels associate with hypertension, hyperglycemia and dysfunctional HDL in acute coronary syndrome patientsCytokines and cellular inflammation - Vascular313Phosphodiesterase5A up-regulation in vascular endothelium under pro-inflammatory conditions: a newly disclosed anti-inflammatory activity for the omega-3polyunsaturated aatty acid docosahexaenoic acid314Cardiovascular risk modifying with extra-low dose anticytokine drugs in rhematoid arthritis315Conversion of human M-CSF macrophages into foam cells reduces their proinflammatory responses to classical M1-polarizing activation316Lymphocytic myocarditis coincides with increased plaque inflammation and plaque hemorrhage in coronary arteries, facilitating myocardial infarction317Serum osteoprotegerin level predictsdeclined numerous of circulating endothelial- derived and mononuclear-derived progenitor cells in patients with metabolic syndromeGrowth factors and neurohormones - Vascular320Effect of gastrin-releasing peptide (GRP) on vascular inflammationSignal transduction - Heart323A new synthetic peptide regulates hypertrophy in vitro through means of the inhibition of nfkb324Inducible fibroblast-specific knockout of p38 alpha map kinase is cardioprotective in a mouse model of isoproterenol-induced cardiac hypertrophy325Regulation of beta-adrenoceptor-evoked inotropic responses by inhibitory G protein, adenylyl cyclase isoforms 5 and 6 and phosphodiesterases326Binding to RGS3 and stimulation of M2 muscarinic acetylcholine receptors modulates the substrate specificity of p190RhoGAP in cardiac myocytes327Cardiac regulation of post-translational modifications, parylation and deacetylation in LMNA dilated cardiomyopathy mouse model328Beta-adrenergic regulation of the b56delta/pp2a holoenzyme in cardiac myocytes through b56delta phosphorylation at serine 573Nitric oxide and reactive oxygen species - Vascular331Oxidative stress-induced miR-200c disrupts the regulatory loop among SIRT1, FOXO1 and eNOS332Antioxidant therapy prevents oxidative stress-induced endothelial dysfunction and Enhances Wound Healing333Morphological and biochemical characterization of red blood cell in coronary artery diseaseCytoskeleton and mechanotransduction - Heart336Novel myosin activator, JSH compounds, increased myocardial contractility without chronotropic effect in ratsExtracellular matrix and fibrosis - Vascular339Ablation of Toll-like receptor 9 causes cardiac rupture after myocardial infarction by attenuating proliferation and differentiation of cardiac fibroblasts340Altered vascular remodeling in the mouse hind limb ischemia model in Factor VII activating protease (FSAP) deficiencyVasculogenesis, angiogenesis and arteriogenesis343Pro-angiogenic effects of proly-hydroxylase inhibitors and their potential for use in a novel strategy of therapeutic angiogenesis for coronary total occlusion344Nrf2 drives angiogenesis in transcription-independent manner: new function of the master regulator of oxidative stress response345Angiogenic gene therapy, despite efficient vascular growth, is not able to improve muscle function in normoxic or chronically ischemic rabbit hindlimbs -role of capillary arterialization and shunting346Effect of PAR-1 inhibition on collateral vessel growth in the murine hind limb model347Quaking is a key regulator of endothelial cell differentiation, neovascularization and angiogenesis348"Emerging angiogenesis" in the chick chorioallantoic membrane (CAM). An in vivo study349Exosomes from cardiomyocyte progenitor cells and mesenchymal stem cells stimulate angiogenesis in vitro and in vivo via EMMPRINEndothelium352Reciprocal regulation of GRK2 and bradykinin receptor stimulation modulate Ca2+ intracellular level in endothelial cells353The roles of bone morphogenetic proteins 9 and 10 in endothelial inflammation and atherosclerosis354The contribution of GPR55 to the L-alpha-lysophosphatidylinositol-induced vasorelaxation in isolated human pulmonary arteries355The endothelial protective ACE inhibitor Zofenoprilat exerts anti-inflammatory activities through H2S production356A new class of glycomimetic drugs to prevent free fatty acid-induced endothelial dysfunction357Endothelial progenitor cells to apoptotic endothelial cell-derived microparticles ration differentiatesas preserved from reduced ejection fractionheart failure358Proosteogenic genes are activated in endothelial cells of patients with thoracic aortic aneurysm359Endothelin ETB receptors mediate relaxing responses to insulin in pericardial resistance arteries from patients with cardiovascular disease (CVD)Smooth muscle and pericytes362CX3CR1 positive myeloid cells regulate vascular smooth muscle tone by inducing calcium oscillations via activation of IP3 receptors363A novel function of PI3Kg on cAMP regulation, role in arterial wall hyperplasia through modulation of smooth muscle cells proliferation364NRP1 and NRP2 play important roles in the development of neointimal hyperplasia in vivo365Azithromycin induces autophagy in aortic smooth muscle cellsCoagulation, thrombosis and platelets368The real time in vivo evaluation of platelet-dependent aldosterone prothrombotic action in mice369Development of a method for in vivo detection of active thrombi in mice370The antiplatelet effects of structural analogs of the taurine chloramine371The influence of heparin anticoagulant drugs on functional state of human platelets372Regulation of platelet aggregation and adenosine diphosphate release by d dimer in acute coronary syndrome (in vitro study)Oxygen sensing, ischaemia and reperfusion375Sirtuin 5 mediates brain injury in a mouse model of cerebral ischemia-reperfusion376Abscisic acid: a new player in cardiomyocyte protection from ischaemia?377Protective effects of ultramicronized palmitoylethanolamide (PEA-um) in myocardial ischaemia and reperfusion injury in vivo378Identification of stem cell-derived cardiomyocytes using cardiac specific markers and additional testing of these cells in simulated ischemia/reperfusion system379Single-dose intravenous metformin treatment could afford significant protection of the injured rat kidney in an experimental model of ischemia-reperfusion380Cardiotoxicity of long acting muscarinic receptor antagonists used for chronic obstructive pulmonary disease381Dependence antioxidant potential on the concentration of amino acids382The impact of ischemia-reperfusion on physiological parameters,apoptosis and ultrastructure of rabbit myocardium with experimental aterosclerosisMitochondria and energetics385MicroRNA-1 dependent regulation of mitochondrial calcium uniporter (MCU) in normal and hypertrophied hearts386Mitochondrial homeostasis and cardioprotection: common targets for desmin and aB-crystallin387Overexpression of mitofusin-2 (Mfn2) and associated mitochondrial dysfunction in the diabetic heart388NO-dependent prevention of permeability transition pore (MPTP) opening by H2S and its regulation of Ca2+ accumulation in rat heart mitochondria389G protein coupled receptor kinase 2 (GRK2) is fundamental in recovering mitochondrial morphology and function after exposure to ionizing radiation (IR)Gender issues392Sex differences in pulmonary vascular control; focus on the nitric oxide pathwayAging395Heart failure with preserved ejection fraction develops when feeding western diet to senescence-accelerated mice396Cardiovascular markers as predictors of cognitive decline in elderly hypertensive patients397Changes in connexin43 in old rats with volume overload chronic heart failureGenetics and epigenetics400Calcium content in the aortic valve is associated with 1G>2G matrix metalloproteinase 1 polymorphism401Neuropeptide receptor gene s (NPSR1) polymorphism and sleep disturbances402Endothelin-1 gene Lys198Asn polymorphism in men with essential hypertension complicated and uncomplicated with chronic heart failure403Association of common polymorphisms of the lipoprotein lipase and pon1 genes with the metabolic syndrome in a sample of community participantsGenomics, proteomics, metabolomics, lipidomics and glycomics405Gene expression quantification using multiplexed color-coded probe pairs to determine RNA content in sporadic cardiac myxoma406Large-scale phosphorylation study of the type 2 diabetic heart subjected to ischemia / reperfusion injury407Transcriptome-based identification of new anti-inflammatory properties of the olive oil hydroxytyrosol in vascular endothelial cell under basal and proinflammatory conditions408Gene polymorphisms combinations and risk of myocardial infarctionComputer modelling, bioinformatics and big data411Comparison of the repolarization reserve in three state-of-the-art models of the human ventricular action potentialMetabolism, diabetes mellitus and obesity414Endothelial monocyte-activating polypeptide-II improves heart function in type -I Diabetes mellitus415Admission glucose level is independent predictor of impaired left ventricular function in patients with acute myocardial infarction: a two dimensional speckle-tracking echocardiography study416Association between biochemical markers of lipid profile and inflammatory reaction and stiffness of the vascular wall in hypertensive patients with abdominal obesity417Multiple common co-morbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress and myocardial stiffening418Investigating the cardiovascular effects of antiretroviral drugs in a lean and high fat/sucrose diet rat model of obesity419Statins in the treatment of non-alcoholic steatohepatitis (NASH). Our experience from a 2-year prospective study in Constanta County, Romania420Epicardial adipose tissue as a predictor of cardiovascular outcome in patients with ACS undergoing PCI?Arterial and pulmonary hypertension423Dependence between heart rhythm disorers and ID polymorphism of ACE gene in hypertensive patients424Molecular mechanisms underlying the beneficial effects of Urocortin 2 in pulmonary arterial hypertension425Inhibition of TGf-b axis and action of renin-angiotensin system in human ascending aorta aneurysms426Early signs of microcirculation and macrocirculation abnormalities in prehypertension427Vascular smooth muscle cell-expressed Tie-2 controls vascular tone428Cardiac and vascular remodelling in the development of chronic thrombo-embolic pulmonary hypertension in a novel swine modelBiomarkers431Arrhythmogenic cardiomyopathy: a new, non invasive biomarker432Can circulating microRNAs distinguish type 1 and type 2 myocardial infarction?433Design of a high-throughput multiplex proteomics assay to identify left ventricular diastolic dysfunction in diabetes434Monocyte-derived and P-selectin-carrying microparticles are differently modified by a low fat diet in patients with cardiovascular risk factors who will and who will not develop a cardiovascular event435Red blood cell distribution width assessment by polychromatic interference microscopy of thin films in chronic heart failure436Invasive and noninvasive evaluation of quality of radiofrequency-induced cardiac denervation in patients with atrial fibrillation437The effect of therapeutic hypothermia on the level of brain derived neurotrophic factor (BDNF) in sera following cardiopulmonary resustitation438Novel biomarkers to predict outcome in patients with heart failure and severe aortic stenosis439Biological factors linking depression and anxiety to cardiovascular disease440Troponins and myoglobin dynamic at coronary arteries graftingInvasive, non-invasive and molecular imaging443Diet composition effects on the genetic typing of the mouse ob mutation: a micro-ultrasound characterization of cardiac function, macro and micro circulation and liver steatosis444Characterization of pig coronary and rabbit aortic lesions using IV-OCT quantitative analysis: correlations with histologyGene therapy and cell therapy447Enhancing the survival and angiogenic potential of mouse atrial mesenchymal cells448VCAM-1 expression in experimental myocardial infarction and its relation to bone marrow-derived mononuclear cell retentionTissue engineering451Advanced multi layered scaffold that increases the maturity of stem cell-derived human cardiomyocytes452Response of engineered heart tissue to simulated ischemia/reperfusion in the presence of acute hyperglycemic conditions453Serum albumin hydrogels prevent de-differentiation of neonatal cardiomyocytes454A novel paintbrush technique for transfer of low viscosity ultraviolet light curable cyan methacrylate on saline immersed in-vitro sheep heart [O] . V Garcia-Martinez, C Lopez Sanchez, W Hamed, 2016

1. Excised Leaf Bioassay: Phenotypic Expression of Natural Resistance in Apple against the Obliquebanded Leafroller [J] . Joseph J. Schwarz ,Jay F. Brunner . 昆虫学（英文） . 2017,第1期

2. 线粒体Sirt3对糖尿病肾小管上皮细胞氧化应激的影响 [C] . 焦晓翠 ,李英 . 第九届中国血液净化论坛暨2017年中国医院协会血液净化中心管理分会年会 . 2017

3. 四逆汤抗HO诱导的氧化应激性损伤保护心肌细胞的线粒体机制研究 [A] . 聂咏梅 . 2005