BACTERIA ENGINEERED TO TREAT DISORDERS IN WHICH TRIMETHYLAMINE (TMA) IS DETRIMENTAL

摘要

The present invention provides recombinant bacterial cells comprising gene sequence encoding one or more trimethylamine catabolism enzyme(s). The recombinant bacterial cells optionally comprise gene sequence encoding one or more TMA and/or TMAO transporter(s). The invention further provides pharmaceutical compositions comprising the recombinant bacteria, and methods for treating disorders in which trimethylamine (TMA) and/or TMAO is detrimental, such as cardiovascular disease, kidney disease, and/or trimethylaminuria, using the pharmaceutical compositions of the invention.