COMPOSITION COMPRISING ENZYME-TREATED ROSA MULTIFLORA FRUIT EXTRACT AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING TH2-MEDIATED IMMUNOLOGICAL DISEASE

摘要

The present invention relates to a composition comprising an enzyme-treated Rosa multiflora fruit extract as an active ingredient for preventing or treating a Th2-mediated immune disease. The composition according to the present invention can maximize the anti-allergic effect of the Rosa multiflora fruit extract by comprising an enzyme-treated Rosa multiflora fruit extract as an active ingredient. Specifically, the present inventors verified that, as a result of treating splenocytes of OVA-immunized mice with an enzyme-treated Rosa multiflora fruit extract, the enzyme-treated Rosa multiflora fruit extract remarkably promoted IL-4 production inhibitory activity compared with an enzyme-non-treated Rosa multiflora fruit extract and the in vivo oral administration of the enzyme-treated Rosa multiflora fruit extract remarkably reduced the blood IgE content in the OVA-immunized mice. In addition, the composition according to the present invention has advantages of being biocompatible and having excellent stability due to the use of Rosa multiflora fruit as a natural material, and thus, the composition is expected to be favorably used in the development of a safe therapeutic agent, a health functional food, a cosmetic product, and the like for the prevention, improvement, or treatment of a Th2-mediated immune disease.