首页> 美国卫生研究院文献>International Journal of Molecular Sciences >A Mixture of Extracts of Kochia scoparia and Rosa multiflora with PPAR α/γ Dual Agonistic Effects Prevents Photoaging in Hairless Mice
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A Mixture of Extracts of Kochia scoparia and Rosa multiflora with PPAR α/γ Dual Agonistic Effects Prevents Photoaging in Hairless Mice

机译:具有PPARα/γ双重激动作用的地肤和多花蔷薇提取物混合物可防止无毛小鼠光老化。

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摘要

Activation of peroxisome proliferator-activated receptors (PPAR) α/γ is known to inhibit the increases in matrix metalloproteinase (MMP) and reactive oxygen species (ROS) induced by ultraviolet light (UV). Extracts of natural herbs, such as Kochia scoparia and Rosa multiflora, have a PPAR α/γ dual agonistic effect. Therefore, we investigated whether and how they have an antiaging effect on photoaging skin. Eighteen-week-old hairless mice were irradiated with UVA 14 J/cm2 and UVB 40 mJ/cm2 three times a week for 8 weeks. A mixture of extracts of Kochia scoparia and Rosa multiflora (KR) was topically applied on the dorsal skin of photoaging mice twice a day for 8 weeks. Tesaglitazar, a known PPAR α/γ agonist, and vehicle (propylene glycol:ethanol = 7:3, v/v) were applied as positive and negative controls, respectively. Dermal effects (including dermal thickness, collagen density, dermal expression of procollagen 1 and collagenase 13) and epidermal effects (including skin barrier function, epidermal proliferation, epidermal differentiation, and epidermal cytokines) were measured and compared. In photoaging murine skin, KR resulted in a significant recovery of dermal thickness as well as dermal fibroblasts, although it did not change dermal collagen density. KR increased the expression of dermal transforming growth factor (TGF)-β. The dermal effects of KR were explained by an increase in procollagen 1 expression, induced by TGF-β, and a decrease in MMP-13 expression. KR did not affect basal transepidermal water loss (TEWL) or stratum corneum (SC) integrity, but did decrease SC hydration. It also did not affect epidermal proliferation or epidermal differentiation. KR decreased the expression of epidermal interleukin (IL)-1α. Collectively, KR showed possible utility as a therapeutic agent for photoaging skin, with few epidermal side effects such as epidermal hyperplasia or poor differentiation.
机译:过氧化物酶体增殖物激活受体(PPAR)α/γ的激活可抑制基质金属蛋白酶(MMP)和紫外线(UV)诱导的活性氧(ROS)的增加。天然草药(如地肤和蔷薇)的提取物具有PPARα/γ双重激动作用。因此,我们研究了它们是否以及如何对光老化皮肤具有抗衰老作用。每周对18周大的无毛小鼠进行UVA 14 J / cm 2 和UVB 40 mJ / cm 2 照射,共8周。每天两次在光老化小鼠的背部皮肤上局部施用地肤和多花蔷薇(KR)提取物的混合物,共8周。 Tesaglitazar(一种已知的PPARα/γ激动剂)和媒介物(丙二醇:乙醇= 7:3,v / v)分别用作阳性对照和阴性对照。测量并比较了皮肤作用(包括皮肤厚度,胶原蛋白密度,前胶原1和胶原酶13的皮肤表达)和表皮作用(包括皮肤屏障功能,表皮增殖,表皮分化和表皮细胞因子)。在光老化的鼠皮中,KR可以显着恢复真皮厚度以及成纤维细胞,尽管它不会改变真皮胶原蛋白的密度。 KR增加了皮肤转化生长因子(TGF)-β的表达。 KR的皮肤作用可通过TGF-β诱导的前胶原1表达的增加和MMP-13表达的减少来解释。 KR不会影响基础经皮水分流失(TEWL)或角质层(SC)的完整性,但会降低SC的水合作用。它还不影响表皮增生或表皮分化。 KR降低了表皮白介素(IL)-1α的表达。集体地,KR显示出可能用作光老化皮肤的治疗剂,几乎没有诸如表皮增生或差的分化的表皮副作用。

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