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REDUCIBLE DEGRADABLE HYPERBRANCHED-POLYMER NANOMICELLE AND METHOD FOR PREPARATION THEREOF AND APPLICATION THEREOF
REDUCIBLE DEGRADABLE HYPERBRANCHED-POLYMER NANOMICELLE AND METHOD FOR PREPARATION THEREOF AND APPLICATION THEREOF
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机译:可还原的可降解的超支化聚合物纳米胶束及其制备方法和应用
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摘要
Provided are a reducible degradable hyperbranched-polymer nanomicelle and a method for preparation thereof and an application thereof. Cystamine and polyethylene glycol diglycidyl ether are polymerized by means of a nucleophilic addition mechanism; in one step, a hyperbranched polymer alternatingly arising from cystamine and polyethylene glycol structural units is synthesized and obtained; then, a hyperbranched nanomicelle is formed by means of self-assembly during the process of dialysis. The hyperbranched-polymer chain segments contain both tertiary aminos and disulfide bond structural units and have pH- and reduction responsiveness, and the hyperbranched three-dimensional cavity structure imparts a drug-carrying ability to the nanomicelle.
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