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INHIBITION AND TREATMENT OF BACTERIAL INFECTIONS BY SEX-SPECIFIC GPER TARGETING

机译：性别特异性G靶子对细菌感染的抑制和治疗

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摘要

The present invention is directed to the use of compounds which are modulators of the G protein-Coupled Estrogen Receptor (GPER) for the inhibition -and/or treatment of Bacterial infections, especially including metMctHin-resistant Staphylococcus aureus (MRSA) infections. Pharmaceutical compositions and methods of treatment of bac terial pathogens, including MRSA are also described.

机译：本发明涉及作为G蛋白偶联雌激素受体（GPER）调节剂的化合物在抑制和/或治疗细菌感染中的用途，特别是包括耐metMctHin的金黄色葡萄球菌。（MRSA）感染。还描述了包括MRSA的细菌病原体的药物组合物和治疗方法。 展开▼

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公开/公告号WO2017123492A1

专利类型

公开/公告日2017-07-20

原文格式PDF

申请/专利权人 STC. UNM;
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申请/专利号WO2017US12687

发明设计人 HALL PAMELA;PROSSNITZ ERIC R.;HATHAWAY HELEN J.;
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申请日2017-01-09

分类号A61K38/17;C07K14/47;A61K31/138;

国家 WO

入库时间 2022-08-21 13:30:22

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1. 降钙素原用于在具有非特异性不适的患者中诊断细菌感染和指导抗生素治疗 [P] . 中国专利： CN102822675B . 2016.06.01

2. 降钙素原用于在具有非特异性不适的患者中诊断细菌感染和指导抗生素治疗 [P] . 中国专利： CN102822675A . 2012-12-12

3. Inhibition and treatment of bacterial infections by sex-specific GPER targeting [P] . 美国专利： US10561648B2 . 2020-02-18

机译：性别特异性GPER靶向抑制和治疗细菌感染

4. INHIBITION AND TREATMENT OF BACTERIAL INFECTIONS BY SEX-SPECIFIC GPER TARGETING [P] . 美国专利： US2019000830A1 . 2019-01-03

机译：性别特异性G靶子对细菌感染的抑制和治疗

5. PEPTIDE, PEGUILLED PEPTIDE, COMPOSITION, PHARMACEUTICAL COMPOSITION, BOTTLE, DISINFECTION SOLUTION, METHOD FOR GROWTH INHIBITION, REPLICATION OR INFECTIVITY OF A MICRO-ORGANISM, METHOD FOR INHIBITION OF A BACTERIAL GROWTH, BACTERIAL GROWTH INHIBITION, TREATMENT OF A MICRO-ORGANISM INFECTION IN A SUBJECT AND PREVENTION OF A DISEASE IN A SUBJECT CAUSED BY OR ASSOCIATED WITH A MICRO-ORGANISM INFECTION, METHOD FOR INHIBITING BACTERIAL GROWTH IN A SUBJECT, A METHOD OF TREATMENT OF A BACTERIAL TREATMENT SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION, METHOD FOR PREVENTING A DISEASE CAUSED BY OR ASSOCIATED WITH A BACTERIAL INFECTION IN A SUBJECT, METHOD FOR INHIBITION OF VIRAL REPLICATION IN A SUBJECT TO A SUBJECT TO A SUBJECT ON A SUBJECT AND TREATMENT OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR THE PREVENTION OF A DISEASE CAUSED BY OR ASSOCIATED WITH A VIRAL INFECTION IN A SUBJECT, METHOD FOR DISINFECTING AN INA [P] . BR112017028190A2 . 2018-09-04

机译：肽，规定的肽，成分，药物成分，瓶，消毒溶液，微生物的生长抑制，复制或感染的方法，细菌生长的抑制方法，细菌生长的抑制作用，治疗由微生物感染引起或与之有关的疾病的预防，疾病的抑制方法，一种细菌治疗方法的治疗和一种或多种细菌引起的疾病的治疗感染，预防由细菌感染引起的疾病或与之相关的疾病的方法，在受试者体内抑制病毒复制的方法以及对由细菌引起或与之相关的疾病的治疗在主题中，一种预防由对象中的病毒感染引起或与之相关的疾病的方法，一种用于对INA进行消毒的方法

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