Controlled release of novel anti-biofilm agents from a poly (2-hydroxyethyl methacrylate) Scaffold for the treatment of medical device associated bacterial biofilm infections

摘要

Incorporation of novel drugs into pHEMA polymers achieved constant drug release rates throughout an extended period of time up to 3 months. Total amounts of drugs released from pHEMA scaffolds in a controlled-sustained manner are sufficient to kill bacteria growth in the liquid phase, as well as to reduce bacteria adhesion on surfaces. Enzyme-based therapies in combination with antimicrobial Ga complexes produced Synergic effects of reducing biofilm formation. Gallium complexes and DispersinTM were promising non-anticbiotic therapeutic drugs both in vitro and in vivo that could be released from the pHEMA scaffolds, thus enhancing the treatment effects to remove bacterial biofilm infections associated on medical devices.