METABOLIC MARKER FOR DIAGNOSING AND DISTINGUISHING CORONARY ATHEROSCLEROSIS AND STABLE ANGINA

摘要

Disclosed is a metabolic marker for diagnosing and distinguishing coronary atherosclerosis and stable angina. The metabolic marker comprises one or more of the following components: a phosphorylcholine, a palmitoylethanolamine, a phytosphingosine, a phosphatidylcholine, a ethylchenodeoxycholic acid, a blood-soluble phosphatidylcholine (16:0), a blood-soluble phosphatidylcholine (18:2), and a phosphatidylinositol (24:0 / 0:0). Single-use of each of the components for diagnosing and distinguishing a patient with stable angina and a patient with coronary atherosclerosis results in an ROC curve with an area under the curve (AUC) of greater than 0.7 in every case, providing diagnostic significance in a clinical setting. Using the components in combination increases the AUC with every additional component in the combination, achieving the highest AUC of 0.985 when all 8 components are used. An optimal cutoff value provides a sensitivity and specificity of 97.4% and 98.0% respectively. The metabolic marker can accurately diagnose and distinguish coronary atherosclerosis and stable angina, offering good accuracy, sensitivity, and specificity.