MARKER GROUP FOR MAKING DIAGNOSIS TO DISTINGUISH CORONARY ARTERIAL ATHEROSCLEROSIS FROM STABLE ANGINA PECTORIS

摘要

A marker group for making diagnosis to distinguish coronary arterial atherosclerosis from stable angina pectoris. The marker group comprises one or more of glutathione, β-hydroxybutyric acid, proline, fumaric acid, phenylalanine and lactic acid. When a single marker is used for making diagnosis to distinguish patients with the stable angina pectoris from patients with the coronary arterial atherosclerosis, the areas under curve (AUC) of a ROC curve are all 0.7 or larger, and the marker has a clinical diagnosis significance; when the marker is used for diagnosis in combination, with the increase of the combination number, the AUC is further increased and reaches 0.988 when 6 markers are combined, and the sensitivity and the specificity are 98.5% and 98.3% respectively under the optimum cutoff value. The metabolic marker group can be used to accurately making diagnosis to distinguish the coronary arterial atherosclerosis from the stable angina pectoris, and has high sensitivity and specificity.