ANGIOGRAPHY METHOD AND SYSTEM BASED ON SPLITTING FULL SPACE OF MODULATION SPECTRUM AND ANGLE-BASED COMBINATION

摘要

An angiography method and system based on splitting a full space of a modulation spectrum and angle-based combination, employing a spatial resolution of optical coherence tomography and a motion identification capability of dynamic light scattering to achieve marker-less three-dimensional optical angiography. Detection light beams having different incident angles are encoded by employing a lateral scan modulation spectrum in the spatial frequency domain, and mutually independent sub-angiograms resolved for each incident angle are acquired by splitting the modulation spectrum, enabling a combined angiogram based on multiple spatial angles. By removing a conjugate mirror image in the depth (z) domain, the present invention enables reconstruction of a complex-valued OCT interference spectrum, and acquisition of a full-space modulation spectrum in the spatial frequency domain, thus preventing interference from the conjugate mirror image on the modulation spectrum. The angle-based combination technique of the angiography method can improve the contrast of an angiogram, the full-space technique in the spatial frequency domain provides a maximized modulation spectrum bandwidth and contrast enhancement, and the detection technique employing multi-angle resolution enables measurement of an absolute blood flow velocity.