MOLECULAR ASSAYS FOR REGULATING IMMUNOSUPPRESSION, AVERTING IMMUNE-MEDIATED REJECTION AND INCREASING GRAFT SURVIVAL

摘要

Disclosed herein are methods of detecting, predicting or monitoring immune-mediated rejection, immunosuppression, or risk of graft loss in a transplant recipient undergoing an immunosuppression regimen. These methods may be useful even In patients with kidney damage not thought to result from ongoing immune activation. Also provided are molecular profiles that more sensitively detect ongoing immune-mediated injury and are a better indicator of later graft loss than standard microscopic biopsy examination.