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NEXT-GENERATION BIOMARKERS TO DETECT SUN DAMAGE AND PREDICT SKIN CANCER RISK
NEXT-GENERATION BIOMARKERS TO DETECT SUN DAMAGE AND PREDICT SKIN CANCER RISK
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机译:下一代生物标志物,可检测日晒损伤和预测皮肤癌风险
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摘要
The present invention provides methods of detecting ultraviolet radiation (UVR)-induced skin damage in a subject. The method includes the steps of: a) obtaining a skin sample from the subject; b) analyzing expression levels in the skin sample of UVR-induced differentially expressed genes (DEGs) listed in Table 8 or a subset thereof; and c) comparing the expression levels of the UVR-induced DEGs to a control skin sample; wherein, when the expression levels of the UVR-induced DEGs in the skin sample is above or below the level of each of the UVR-induced DEGs in the control sample, the subject is identified as likely being afflicted with UVR-induced skin damage. Also provided are methods for measuring the effectiveness of a test agent in reducing ultraviolet radiation (UVR)-induced damage.
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