WISP1 ANTIGEN BINDING PROTEINS THAT BIND WISP1

摘要

Compositions and methods related to or derived from anti-WISP1 antibodies are disclosed. More specifically, WISP1-binding polypeptides that include a fully human antibody, a WISP1-binding fragment, and derivatives of the antibodies, and fragments thereof that bind to WISP1 are disclosed. In addition, there is further provided a nucleic acid encoding said antibody, antibody fragment and derivative and polypeptide, a cell comprising said polynucleotide, a method of producing said antibody, antibody fragments and derivatives and polypeptides, and a method of producing a polypeptide having a WISP1 related disorder or condition Methods of using the antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing a subject, are disclosed. Also disclosed are methods of treating or preventing various cancer or inflammatory diseases and various diseases of the heart, bone / joint or lung.