Adhesive sealant for treating of fistula perforation or anastomosis leak and for connecting of internal organ

摘要

The present invention relates to a cationic protein comprising a catechol derivative, in particular an adhesive sealant for joining internal organs using coacervate based on mussel adhesive protein and for treating fistula, perforation or anastomotic leakage, and a method for producing the same. The sealant according to the present invention can be produced by using an underwater adhesive composition comprising a cationic protein including a catechol derivative and a coacervate crosslinked with an anionic polymer, thereby exhibiting excellent biocompatibility and exhibiting high water solubility in both organic and inorganic surfaces It is possible to treat joints of internal organs, leakage of fistula, perforation or anastomotic leakage, and particularly, it is possible to treat fistula of bladder which repeats contraction and swelling.;