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IgG Fc A stable liquid formulation of fusion protein with IgG Fc domain
IgG Fc A stable liquid formulation of fusion protein with IgG Fc domain
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机译:IgG Fc具有IgG Fc结构域的融合蛋白的稳定液体制剂
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摘要
The present invention relates to a stable liquid formulation of a fusion protein having an Fc domain of a human immunoglobulin G (IgG), in particular, a protein in which an Fc domain of a human immunoglobulin G (IgG) and a soluble extracellular domain of a vascular endothelial growth factor (VEGF) receptor are fused (e.g., aflibercept). The present invention also relates to a composition for stabilizing a protein and a method for stabilizing a protein in which an Fc domain of an IgG and a soluble extracellular domain of a VEGF receptor are fused. The present invention improves therapeutic effects with respect to various ophthalmic diseases (e.g., retinal vein occlusion, diabetic macular edema, choroidal neovascularization and wet age-related macular degeneration, etc.) caused by abnormal angiogenesis, while assisting stabilization of bioactivity through a stable liquid formulation suitable for intravitreal injection of an anti-VEGF-Fc fusion protein including aflibercept.
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