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IgG Fc A stable liquid formulation of fusion protein with IgG Fc domain
IgG Fc A stable liquid formulation of fusion protein with IgG Fc domain
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机译:IgG Fc具有IgG Fc结构域的融合蛋白的稳定液体制剂
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摘要
The present invention relates to a stable liquid formulation of a protein (for example, an aflibercept) in which an Fc domain of human immunoglobulin G (IgG) is fused with a soluble extracellular domain of a fusion protein (in particular, a vascular endothelial growth factor (VEGF)) receptor having an Fc domain of human immunoglobulin G (IgG). Additionally, the present invention relates to a composition for stabilizing a protein in which a soluble extracellular domain of a VEGF receptor is fused with an Fc domain of IgG; and to a method of stabilizing a protein in which a soluble extracellular domain of a VEGF receptor is fused with an Fc domain of IgG. By using a stable liquid formulation appropriate for intravitreal injection of an anti-VEGF-Fc fusion protein including an aflibercept, the present invention can promote the stabilization of biological activity while improving the treatment effects on various ocular diseases caused by abnormal angiogenesis (examples: retinal vascular occlusion, diabetic macular edema, choroidal neovascularization, and wet age-related macular degeneration).
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