IgG Fc A stable liquid formulation of fusion protein with IgG Fc domain

摘要

The present invention relates to a fusion protein having the Fc domain of human immunoglobulin G (IgG), particularly the soluble extracellular domain of the vascular endothelial growth factor (VEGF) receptor and the Fc domain of human immunoglobulin G (IgG) And a fusion protein thereof (e.g., an influenzacept)]. The present invention also relates to a composition for stabilizing a protein in which a soluble extracellular domain of a VEGF receptor is fused with an Fc domain of an IgG, and a method for stabilizing a protein in which a soluble extracellular domain of a VEGF receptor is fused with an Fc domain of an IgG. The present invention provides a stable liquid formulation suitable for intraocular injection of an anti-VEGF-Fc fusion protein including Aflibercept to stabilize the physiological activity and to prevent various ocular diseases caused by abnormal angiogenesis (for example, retinal vein occlusion , Diabetic macular edema, choroidal neovascularization, habitual age-related macular degeneration, etc.).