CD3 ANTIBODIES BINDING TO HUMAN AND CYNOMOLGUS CD3 EPSILON

摘要

One embodiment as reported herein is a nucleic acid molecule that specifically binds to the human CD3 epsilon of SEQ ID NO: 2 and specifically binds to the polypeptide of SEQ ID NO: 1 and specifically binds to human and cynomolgus T cells, In order to produce human cytoplasmic cross-reactive antibodies that activate human T cells and do not bind to the same epitope as antibody OKT3, antibody UCHT1 and / or antibody SP34, the experiment was repeated three times with primary cynomolgus PBL The method comprising immunizing a subject comprising the step of arbitrarily enhancing PBL against T cells without using a primary human PBL as an immunogen and without using a denaturant.