EPO PKC Pharmaceutical composition for preventing or treating anemia comprising agent targeting EPO receptor as well as PKC as an active ingredient and the use thereof

摘要

The present invention provides a pharmaceutical composition for preventing or treating anemia comprising an agent targeting an erythropoietin receptor (EPOR) as well as a protein kinase C (PKC) as an active ingredient. The agent targeting the EPOR as well as the PKC has effects of promoting proliferation of cells in EPO-dependent cell lines, and of relieving the anemia in an animal model of the anemia. The agent targeting the EPOR shows synergistic effects in an activation of the EPO when colonies of red blood cells are formed, and an activation of hematopoiesis in a living body was confirmed, thereby being used for preventing or treating the anemia. Thus, the pharmaceutical composition comprising the agent targeting the EPOR as well as the PKC as the active ingredient can be used as the composition for preventing or treating the anemia.