EPO PKC Pharmaceutical composition for preventing or treating anemia comprising agent targeting EPO receptor as well as PKC as an active ingredient and the use thereof

摘要

The present invention provides a pharmaceutical composition for preventing or treating anemia comprising an EPO receptor and a PKC co-target substance as an active ingredient. The EPO receptor and the PKC co-targeting substance exhibit cell proliferation promoting activity in an EPO-dependent cell line, exhibit anemia mitigation efficacy in an animal model of anemia, exhibit a synergistic effect on EPO activity in erythrocyte colony formation, To be used for the prevention or treatment of anemia. Accordingly, the pharmaceutical composition comprising the EPO receptor and the PKC co-targeting substance as an active ingredient can be usefully used as a pharmaceutical composition for the prevention or treatment of anemia.;