Fast acting oral disintegration films (ODF) are provided for the treatment of various medical conditions, including vomiting with a pharmacokinetic profile similar to that of currently commercially available oral pharmaceutical products, which are easy to manufacture with simple formulations. Characterized in that the ODF has an active pharmaceutical ingredient such as an ondansetron in an amount of from 2 to 24 mg, or a pharmaceutically acceptable salt thereof, having a molecular weight of from 5000 to 50000 Da, at least one hydrophilic Film forming polymer, and water-soluble excipients in an amount of 10 to 30% by weight of the film. The present invention also relates to a method for the preparation of ODF which remains stable over time under normal pharmacological storage conditions and for the treatment or prevention of various medical conditions such as nausea and vomiting by administering ODF to the required patient, RTI ID = 0.0 5HT / RTI
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