FXR/TGR5 BILE ACID ANALOGS AS FXR/TGR5 DERIVATIVES AND METHODS OF USE THEREOF

摘要

The present invention provides amino-substituted bile acid derivatives, pharmaceutical compositions comprising such compounds, and methods of using such compounds to prevent or treat FXR-mediated or TGR5-mediated diseases or conditions. In one embodiment, the invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound or combination of compounds of the invention, or a pharmaceutically acceptable salt, stereoisomer, solvate, hydrate or combination thereof, In combination with a carrier or excipient. .