T enriched T USE OF ANTIBODIES FOR ENRICHMENT OF ENGINEERED T CELLS WITH EXOGENOUS IMMUNE RECEPTORS AND ANTIBODIES FOR USE IN DEPLETION OF ENGINEERED T CELLS

摘要

The present invention provides an exogenous immunoreceptor that does not require any additional selectable marker genes and / or any additional self-destructive genes. The present invention allows the production of engineered T cells that can be enriched in a non-contact manner. In other words, engineered T cells do not require interaction with any external agent, and can be selected by removing T cells that express endogenous alpha beta T cell receptors. Engineered T cells with an exogenous immunoreceptor that can be distinguished from endogenous T cell receptors are provided and can be removed, i. E., Depleted, with a specifically targeting antibody that specifically targets the foreign immunoreceptor.