PHARMACEUTICAL COMPOSITION FOR INHIBITING AUTOPHAGY OF MOTOR NEURONS AND USE THEREOF

摘要

A pharmaceutical composition comprising an effective amount of an active ingredient selected from the group consisting of a compound of formula (I), a pharmaceutically acceptable salt of a compound, a pharmaceutically acceptable ester of a compound and a combination thereof, Composition: (I) (I), A is C1-C5 alkyl optionally substituted with one or more unsaturated bonds and optionally substituted with one or more substituents selected from the group consisting of-OH, = O, and C1-C3 alkyl; X is H , -OH, , or ego; Y is O or S, optionally combined with A to form a 5 membered ring; R ₁ is H or substituted or unsubstituted C 1 -C 20 alkyl, wherein one or more -CH ₂ - of C ₁ -C 20 alkyl is optionally replaced by -NH- or -O-.