ATHEROSCLEROSIS AND INFLAMMATORY DISEASE PREVENTING OR TREATING PHARMACEUTICAL COMPOSITION CONTAINING LOVASTIN

摘要

The present invention relates to a novel use of a metabolome, lovastin, derived from a natural material. More specifically, the present invention relates to an atherosclerosis or inflammatory disease preventing or treating pharmaceutical composition of lovastin isolated from Stereocaulon alpinum. An atherosclerosis or inflammatory disease preventing or treating pharmaceutical composition containing lovastin as an active ingredient according to the present invention blocks an activity of NF-B with respect to an inflammation reaction, inhibits a signal delivery pathway of p38 and ERK 1/2, inhibits expression of TNFR1, and inhibits generation of a reactive oxygen species (ROS). Thus, it has been confirmed that lovastin inhibits expression of a blood vessel cell attaching molecule (VCAM-1) induced by TNF-, and lovastin does not have cytotoxicity. Thus, lovastin can be useful as atherosclerosis or inflammatory disease preventing or treating pharmaceutical composition.;COPYRIGHT KIPO 2017