GSK3 Nitrogen-Containing Heteroaryl Derivatives and Their Use as GSK3 Inhibitors

摘要

The present invention provides a novel compound of formula (I) or a pharmaceutically acceptable salt thereof having GSK3? Inhibitory activity. [Chemical Formula 1] In Formula 1, X is carbon (C) or nitrogen (N); Y is carbon (C) or oxygen (O); R ₁ is hydrogen, aryl, -CO-aryl or heteroaryl, wherein said aryl or heteroaryl may be unsubstituted or substituted; R ₂ is _{-CO-NH- (CH 2) n} -CO-NH-, -CO-O- (CH 2) n -, -CH = CH- (CH 2) m -CO-NH- or - (CH ₂ ) _n- CO-NH-, wherein n is an integer from 1 to 3 and m is an integer from 0 to 3; R ₃ is C _1-6 alkyl, - (CH ₂ ) _n -aryl, - (CH ₂ ) _n -heteroaryl or - (CH ₂ ) _n -heterocyclyl wherein the aryl, heteroaryl or heterocyclyl May be unsubstituted or substituted. The compound of Formula 1 is useful for preventing or treating a disease associated with GSK3 [beta], i.e., a proliferative disease, a neurodegenerative or neurodegenerative disease, an inflammatory autoimmune disease, a cardiovascular disease, an endocrine disease, and a viral infectious disease.