Heteroaryl amines - derivatives of pyrimidine and pyridazine as inhibitors of glycogenesis synthase kinase 3-beta (GSK3 inhibitors)

摘要

This invention relates to a compound of formula (I) with its N-oxide, pharmaceutically acceptable addition salt, quaternary amine and stereochemically isomeric form, wherein ring A is a 6-membered substituted heterocyclyl derivative of pyrimidinyl or pyridazinyl; R is hydrogen; aryl; formed; C-alkylcarbonyl; optionally substituted C1-6alkyl; C1-6alkyloxycarbonyl; optionally substituted C1-6 alkyloxycarbonyl; X is a direct bond or a linker atom or a linker group; Z is a direct bond or a linker atom or a linker group; R1 is hydrogen, C1-6alkyl, C1-6alkenyl, C1-6alkynyl, carbocycle or heterocycle, each of these groups may be optionally substituted; R is hydrogen; hydroxy; halogen; optionally substituted C1-6alkyl or C1-6alkenyl or C1-6alkynyl; C1-6 alkyloxy; C1-6alkylthio; C1-6alkyloxycarbonyl; C1-6alkylcarbonyloxy; carboxyl; cyano; nitro; amino; mono- or di (C1-6alkyl) amino; polyhaloSalkyl; polyhaloSalkyloxy; polyhaloSalkylthio; R; R-C1-6alkyl; R-O-; R-S-; R-C (= O) -; R-S (= O) -; R-S (= O) -; R-S (= O) -NH-; R-S (= O) -NH-; R-C (= O) -; -NHC (= O) H; -C (= O) NHNH; R-C (= O) -NH-; R-C (= O) -NH-; -C (= NH) R; -C (= NH) R; R 1 is an optionally substituted heterocycle, with the proviso that —X — R 1 and / or R is other than hydrogen; their use, pharmaceutical compositions containing them and methods for their preparation.