Kv4.1 Methods of screening anti-epileptic or cognitive impairment drugs using Kv4.1 channel

摘要

The present invention includes the steps of: processing the nerve cells expressing the potassium channel Kv4.1 the disorder therapeutic agent candidate whether or seizure; Measuring the activity or expression level of the Kv4.1 potassium channel in a neuronal cell process seizures or cognitive disorder therapeutic agent candidate in the above step; And if the amount of activity or expression of the Kv4.1 potassium channel measured in the above step increases than the control not treated with nerve disorder therapeutic candidates that the seizure or cells, the seizure, or cognitive disorders therapeutic candidates to seizure or treatment cognitive disorders in comprising the step of determining, seizures or screening method for a therapeutic agent cognitive disorders, and screening kits of the seizure or treatment cognitive disorders, including means for measuring the activity of Kv4.1 potassium channels in neurons expressing the potassium channel Kv4.1 It relates. The invention also care that express how black the efficacy of seizures or cognitive disorders and the treatment of potassium channel Kv4.1, by measuring the activity or expression level of the potassium channel Kv4.1 in neural cells expressing the potassium channel Kv4.1 in the cell related to the efficacy test kit comprising means for measuring the activity of the potassium channel Kv4.1. Kv4.1 potassium channel of the present invention may be screened for new seizures or cognitive disorder therapeutic agent through the Kv4 channel in relation to the other and independently of independently seizures or symptoms of cognitive disorders in accordance with the activity and the expression of regulated, measuring it, it can easily test the efficacy of existing drug seizures or cognitive dysfunction effectively.;