SMALL MOLECULE DETECTION AND LOCALIZATION METHOD BASED ON MALDI MASS SPECTROMETRY IMAGING

摘要

The present invention relates to a method for determining inhibition of neovascularization using Mali mass spectrometry, and more particularly, to a method for determining the presence or distribution of a small molecule used as a drug in a sample using Mali mass spectrometry, The result of the analysis was compared with the result of immunofluorescent staining for the target protein of the small molecule used as the drug, and the binding between the small molecule and the target protein and the binding distribution of the small molecule and the target protein were measured. The present invention relates to a method for determining that angiogenesis is inhibited in a region where an area where a target protein is present is overlapped as a result of immunofluorescence staining.