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THERAPY AND METHOD OF INTRA-TUMOR INTRODUCTION OF CYTOTOXIC T-LYMPHOCYTES AND / OR NKT CELLS WITH ANTIBODY AGAINST TNF AND / OR ANTIBODY AGAINST IL-10
THERAPY AND METHOD OF INTRA-TUMOR INTRODUCTION OF CYTOTOXIC T-LYMPHOCYTES AND / OR NKT CELLS WITH ANTIBODY AGAINST TNF AND / OR ANTIBODY AGAINST IL-10
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机译:肿瘤内导入具有抗TNF和/或抗IL-10抗体的细胞毒性T淋巴细胞和/或NKT细胞的治疗和方法
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摘要
The invention relates to therapy and methods of applying the therapy to cancer patients. The invention includes introducing intratumorally cytotoxic T lymphocyte and/or NKT cells, and prior to, coincident with, or following introducing intratumorally the cytotoxic T lymphocyte and/or NKT cells, introducing intratumorally anti-TNF and/or anti-IL-10 to the patient. The cytotoxic T lymphocyte and/or NKT cells can be induced by the intratumoral introduction of immature dendritic cells to the patient. This therapy of the invention can be effective to regress, reduce or eliminate tumor cells in tumor tissue of the patients in the absence of radiation therapy.
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