USE OF ADAMANTANE-CONTAINING INDOLES AND THEIR HYDROCHLORIDES AS CYTOPROTECTORS AND FOR TREATING AND PREVENTING DISEASES ASSOCIATED WITH INCREASE IN CYTOSOLIC CALCIUM CONCENTRATION AND PHARMACOLOGICAL AGENT BASED THEREON

摘要

FIELD: chemistry; pharmacology.;SUBSTANCE: invention relates to use of adamantane-containing indole derivatives and their hydrochlorides of general formula 1, where R₁, R₂, R₃, R₄ can be identical or different and independently represent H, F, Cl, Br, (C₁-C₆)alkyl, (C₁-C₆)alkoxy; R₅, R₆ can be identical or different and independently represent H, (C₁-C₆)alkyl, ONO₂; X is CH₂CH(OH)CH₂ or CH₂CH₂C(O); Z = no, Cl; as cytoprotectors in treating and preventing of diseases associated with increase in cytosolic calcium concentration.;EFFECT: treatment and prevention of diseases associated with increase in cytosolic calcium concentration.;31 cl, 9 dwg, 8 ex; ,