compound, methods for increasing the concentration of d-serine and / or decreasing the concentration of toxic d-serine oxidation by donation in a mammal, to treat schizophrenia, to treat or prevent associated memory and / or cognition loss. with Alzheimer's disease, to treat ataxia or to prevent loss of neuronal function characteristic of neurodegenerative diseases, to enhance learning, memory and / or cognition and to treat neuropathic pain, and, pharmaceutical composition

摘要

"COMPOSITE, METHODS FOR INCREASING CONCENTRATION OF D-SERINE AND / OR DECREASING CONCENTRATION OF DAAO TOXIC D-SERINE OXIDATION IN A MAMMER, TO TREAT SCHIZOPHRENIA, TO TREAT OR PRECERATE OR PRECERATE ASSOCIATED WITH ALZHEIMER EVIL, TO TREAT ATAXIA OR TO PREVENT LOSS OF NEURONAL FUNCTION CHARACTERISTIC OF NEURODEGENERATIVE DISEASES, TO INCREASE LEARNING, MEMORY AND / OR COGNITION, AND TO TREAT NEURODIA. Methods for increasing the concentration of D-Serine and reducing the concentration of toxic D-Serine oxidation products, for enhancing learning, memory and / or cognition or for treating schizophrenia, Alzheimer's disease, ataxia or neuropathic pain or preventing loss in neuronal function characteristic of neurodegenerative disorders involves administering to a patient in need of treatment a therapeutically effective amount of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein R¬1¬ and R¬2 ¬ are independently selected from hydrogen, halo, nitro, alkyl, acyl, alkylaryl and XYR¬ 5¬; or R 1 and R 2 taken together form a substituted or unsubstituted 5-, 6-, 7- or 8-membered carbocyclic or heterocyclic group; X and Y are independently selected from O, S, NH and (CR¬ 6¬R¬ 7¬) ~ n ~; R¬ 3¬ is hydrogen, alkyl or M +; M is aluminum ion, calcium, lithium, magnesium, potassium, sodium, zinc or a mixture thereof; Z is N or CR¬4¬; R¬ 4¬ is selected from hydrogen, halo, nitro, alkyl, alkylaryl and XYR¬ 5¬; R¬5¬ is selected from aryl, substituted aryl, heteroaryl and substituted heteroaryl; R¬6¬ and R¬7¬ are independently selected from hydrogen and alkyl; n is an integer from 1 to 6; at least one of R¬ 1¬, R¬ 2¬ and R¬ 4¬ is other than hydrogen; and at least one of X and Y is (CR¬ 6¬R¬ 7¬) ~ n ~. D-serine or cycloserine may be co-administered together with the compound of formula (I).