ANTIMICROBIAL COMBINATION IN TERMS OF CARBAPENEM RESISTANTGRAM-NEGATIVE PSEUDOMONAS AERUGINOSA BACTERIA, PRODUCING METAL-β-LACTAMASE

摘要

FIELD: biotechnology.;SUBSTANCE: invention describes jointly-used antimicrobial combinations of bisphosphonates and carbapenems against carbapenem-resistant gram-negative Pseudomonas aeruginosa ATCC 27853 bacteria, producing β metal-lactamase. Antimicrobial combination are characterized by the weight ratio of components, namely of a combination of imipenem/clodronic acid, meropenem/clodronic acid, imipenem/etidronic acid, meropenem/etidronic acid are used in ratios of 1:469, 1:3750, 1:25000, 1:25000, respectively.;EFFECT: possibility of application to overcome resistance to carbapenems in gram-negative Pseudomonas aeruginosa ATCC 27853 bacteria.;16 tbl