ASSESSMENT METHOD FOR PROTECTIVE POTENCY OF PERTUSSIS VACCINES

摘要

FIELD: biotechnology.;SUBSTANCE: pertussis vaccines are introduced intranasally followed by intranasal inoculation of virulent B. bronchiseptica, B. parapertussis or B. pertussis bacterium in lethal doses and the survival rate of vaccinates is determined.;EFFECT: method provides for a realistic pattern of pertussis immunity and reliable determination of quantitative characteristics of protective potency.;4 cl, 3 ex, 4 tbl