ADHESIVE POLYMERIC SOLUBLE FILM FOR DRUG DEPOSITION ON SURFACE OF NASAL AND SUPRA-LATERAL SINUS MUCOSA

摘要

FIELD: medicine.;SUBSTANCE: film contains, wt %: hydroxypropylmethylcellulose - 30, pectin - 20, lidocaine hydrochloride - 10, Polysorb MP - 10 and distilled water - the rest. Film composition provides a high adhesiveness to the mucosa and an increase in time of drug deposition, sorption, antiseptic and analgesic effect due to this. The film may further drugs, such as xylometazoline, metronidazole and/or prednisolone, to provide, respectively, vasoconstrictive, antibacterial and/or anti-inflammatory effects. The proposed film can be successfully used to treat various forms of rhinitis, sinusitis, after surgery on the nasal concha and maxillary sinus during rehabilitation and as a means of maintenance therapy.;EFFECT: effectiveness of treatment is significantly increased due to additional medicinal substances added to the film, correction of the type and time of use of the prescribed therapeutic preparations.;4 cl, 2 ex