Method and system for processing MRI data of the human brain

摘要

A method of processing MRI data of a patient's human brain comprising voxel-resolved three-dimensional MRI data of the patient brain and brains of a normal population of a plurality of neurologically healthy human individuals, wherein - by means of a classification algorithm, the MRI data of the patient brain for each voxel segmented into fractions of gray matter, white matter and cerebrospinal fluid, - the MRI data are transformed into a standardized stereotactic space for comparison with the MRI data of the normal population, yielding one or more normalized tissue maps corresponding to the proportions determined by the classification algorithm wherein the transformation occurs before, after or in synchrony with the segmentation, and - the tissue map or tissue maps of the patient's brain for a voxel-based statistical comparison with the correspondingly normalized and segmented MRI data of the normal population vs, wherein the voxel-based statistical comparison of the tissue map or tissue maps is a morphometric comparison, wherein such statistically significant voxels are identified in the tissue map or tissue maps of the patient's brain that belong to a white matter-dominated area and where more gray matter is present than is to be expected by the normal collective or belong to a region dominated by the gray matter and in which more white matter is contained than is to be expected by the normal collective, characterized in that an additional test is carried out, wherein a Three-dimensional mask is created in whose area the white or gray substance dominates, for the area of the mask the values of the tissue maps for white and gray matter of the patient and the data of the normal collective are summed up separately and thus for the patient and the normal role ktiv each obtains volume values for the total amount of gray and white matter within the mask, which are set in relation to each other.