COMBINATION OF A CARDIAC STEROID AND AN AKT INHIBITOR FOR THE TREATMENT OF CARDIOVASCULAR DISEASES AND DISORDERS

摘要

The present invention relates to pharmaceutical combinations for the treatment of cardiovascular diseases and disorders. More particularly, the invention relates to pharmaceutical combinations comprising a cardiac steroids CS and at least one PI3K/Akt/m TOR inhibitor. The compositions of the invention may particularly be used for reducing the CS dose administered to a subject suffering from a cardiovascular disease or disorders, thereby reducing the side effects associated with CS therapy. The invention further provides methods of treatment of such diseases and disorders using the pharmaceutical combinations.