TITANIUM CLIP WITH DRUG-LOADING FEATURE, DRUG-LOADED TITANIUM CLIP, AND MANUFACTURING METHOD THEREOF

摘要

The present invention discloses a preparation method of a titanium nail capable of loading a drug. The titanium nail capable of loading a drug includes a titanium nail body capable of loading a drug, and a microporous ceramic layer capable of loading a drug arranged on the surface of the titanium nail body. The steps of the method include: pretreating the surface of the titanium nail body, preparing a microporous mould for hyaluronic acid-alginic acid microspheres, preparing a titanium sol solution, coating film, pore-forming and roasting. The present invention also discloses a titanium nail capable of loading a drug obtained by the preparation method above, and a drug-loaded titanium nail prepared with the titanium nail capable of loading a drug and a preparation method thereof. With the microporous ceramic layer on the surface of the titanium nail body, it is hard for the metal ions on the surface of the titanium nail to penetrate the human body, due to the properties of corrosion resistance and wear resistance of the ceramics. Further, it fails to generate the exfoliations and the wear debris to prevent the human body from "wear debris disease" and reaction to a foreign body. Moreover, various drugs such as the antibacterial drugs, and the drugs for promoting the healing etc. can be loaded, targeted and slow-released, which is good for medical usage.