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METHOD OF ASSESSING SAFETY OF INFLUENZA VACCINE

机译:流感疫苗安全性评估方法

摘要

PROBLEM TO BE SOLVED: To provide a method that can appropriately assess the safety of an influenza vaccine.;SOLUTION: The method comprises: a step of measuring the average value of the expression level of each gene included in a gene set which increases expression when a test animal is vaccinated with an inactivated influenza vaccine; and a step of acquiring information related to the safety of the inactivated influenza vaccine on the basis of a comparison result of comparing the measured average value and a threshold value for classifying side reaction risk of the influenza vaccine calculated by a logistic regression model into zones.;SELECTED DRAWING: Figure 9;COPYRIGHT: (C)2018,JPO&INPIT
机译:解决的问题:提供一种可以适当地评估流感疫苗安全性的方法;解决方案:该方法包括:测量基因组中每个基因表达水平的平均值的步骤,该平均值会增加给测试动物接种灭活的流感疫苗;根据比较结果,将通过logistic回归模型算出的流感疫苗副反应风险的测定平均值与阈值进行比较,得到与灭活流感疫苗的安全性有关的信息的步骤。 ;选定的图纸:图9;版权:(C)2018,JPO&INPIT

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