CYSTATHIONINE-γ-LYASE (CSE) INHIBITORS

摘要

PROBLEM TO BE SOLVED: To provide compounds and pharmaceutical compositions containing such compounds which inhibit cystathionine-γ-lyase (CSE).SOLUTION: There is provided a compound of formula (I) in the figure, or a pharmaceutically acceptable salt, solvate or prodrug thereof. (A is a carboxylic acid isostere; X is CR, or N; Ris H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, or the like; Rand Rare each independently H, substituted or unsubstituted alkyl, or the like.)SELECTED DRAWING: Figure 10