METHODS AND COMPOSITIONS FOR PROMOTING AXON REGENERATION AND NERVE FUNCTIONS

摘要

PROBLEM TO BE SOLVED: To provide methods and compositions for promoting axon regeneration in CNS neurons.SOLUTION: The invention relates to a method for promoting axon regeneration by exposing a CNS neuron to an effective amount of a necrosis inhibitor and an effective amount of apoptosis inhibitor, and a composition comprising a pharmaceutically acceptable carrier, a necrosis inhibitor and an apoptosis inhibitor. The necrosis inhibitor is preferably necrostatin, the apoptosis inhibitor is preferably a pan-caspase inhibitor, in particular, zVAD, IDN-6556 having a dipeptide structure.SELECTED DRAWING: None