Methods for treating neuroendocrine tumors overexpressing somatostatin receptors

摘要

The present invention relates to a method of treating cancers that overexpress the somatostatin receptor. More specifically, the present invention provides a combination therapy where a combination of peptide receptor radionuclide therapy (PRRT) and immuno-oncology therapy (IO therapy) is administered for the treatment of neuroendocrine tumors. . In a specific embodiment, the PRRT is [177] Lutetium-DOTA [O] -Tyr [3] -octreotate and IO therapy involves the PD-1 / PD-L1 and CTLA-4 pathways. Administering an inhibitor that inhibits.