Methods for recruitment and use of T cells with enhanced reconstitution ability and lifespan

摘要

The present disclosure relates to peripheral blood nave / memory stem cells with enhanced reconstitution ability and / or long life (ie, (T_N) / T_SCM// T_CM) T cells. It is disclosed that this particular subset of T cells can be recruited by administering at least one mobilizing factor in combination with at least one E-selectin inhibitor. In one aspect, there is provided a method for treating peripheral blood of a subject having T_NaiveT_CMT_SCM, CD62L^HighCCR 7⁺, CD 8⁺CD62L^HighCCR 7⁺, CD 8⁺CD62L^High, CD44^-CD 8⁺CD62L^HighOr CD44⁺CD 8⁺CD62L^HighAnd combinations thereof is provided, the method comprising administering to the subject at least one mobilization factor in combination with at least one E-selectin inhibitor .