METHOD AND COMPOSITION FOR ENHANCED ANTI-TUMOR EFFECTOR FUNCTIONING OF T CELLS

摘要

PROBLEM TO BE SOLVED: To provide a method and a composition for enhanced anti-tumor effector functioning of CD4+ and CD8+ T cells for cancer immunotherapy; and provide, in particular, an extracellular domain.SOLUTION: The present invention provides a tumor-specific chimeric antigen receptor which comprises a specific recognition element, an optional support or linker region, a transmembrane region, the signaling domain of CD3 zeta chain and the signalling domain of at least one additional costimulatory signaling receptor.SELECTED DRAWING: None