Serotype cross-reactive dengue heat neutralizing antibody and use thereof

摘要

Disclosed are isolated antibodies that bind to dengue virus epitopes, or antigen-binding fragments thereof, and kits containing them, compositions containing them, and passive vaccines containing them, in one embodiment, antibodies or antigens thereof Binding fragments can be bound by the entire dengue virus particle rather than by binding to glycoproteins on the surface of dengue virus. Also disclosed are methods using antibodies, or antigen-binding fragments thereof, nucleic acids encoding them, vectors expressing the nucleic acids, hosts producing them, and methods for producing them. [Selection] Figure 21