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Serotype cross-reactive, dengue neutralizing antibody and uses thereof
Serotype cross-reactive, dengue neutralizing antibody and uses thereof
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机译:血清型交叉反应,登革热中和抗体及其用途
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摘要
Disclosed are isolated antibodies, or antigen binding fragments thereof, that bind to dengue virus epitopes, as well as kits containing them, compositions containing them, and passive vaccines comprising them, in one embodiment, the antibody or antigen binding fragment thereof is capable of binding to a whole dengue virus particle better than binding to a dengue virus surface glycoprotein. Also disclosed are methods of using the antibodies or antigen binding fragments thereof, nucleic acids encoding them, vectors expressing the nucleic acids, host producing them, and methods of manufacturing them.
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