Treatment of CNS disease with encapsulated inductive choroid plexus cells

摘要

Encapsulated pathogen-free heterogeneous choroid plexus (CP) cells induced to produce altered (in certain embodiments, increased) levels of one or more cerebrospinal fluid (CSF) components. Disclosed are compositions and methods for improved treatment of nervous system diseases and disorders using CNS implantable semipermeable biocompatible capsules containing. The capsules, as disclosed, induce increased levels of CSF production by CP cells that are prominently (greater than 16 months after implantation) without eliciting immunological rejection, inflammation, or foreign body response. Is selected to be possible.